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A Manufacturer's submitted price. 2 b Daily drug cost calculated assuming "monthly" injections are given every 28 days, consistent with the manufacturer's assumptions and confirmed via consultation with a clinical expert. c Saskatchewan Formulary (accessed April 2017). 5 d Alberta Health Drug Benefit Formulary (accessed March 2017). 6 e Methotrexate inhibits the enzyme dihydrofolate reductase, essential for the synthesis of purines and pyrimidines. Indications and dose Severe Crohn's disease By subcutaneous injection, or by intramuscular injection Child 7-17 years 15 mg/m 2 once weekly (max. per dose 25 mg). Maintenance of remission of severe Crohn's disease Methotrexate cost As with all medications, the cost of methotrexate can vary. Factors that may affect the price you'll pay include your treatment plan, your insurance coverage, and the... Injection of methotrexate under your skin. This is called a . subcutaneous (SQ or SubQ) injection. 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