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We conducted a multicentre randomized, double-blind trial to compare the efficacy of 0.3% nifedipine and 1.5% lidocaine ointment versus 1.5% lidocaine ointment alone in reducing pain after. Measures and outcomes: In this study, 200 patients with stage I or II PU according to 2-digit Stirling Pressure Ulcer Severity Scale were randomized to receive topical nifedipine 3% ointment or... Nifedipine ointment is used for the treatment of anal fissures. Anal fissures are tears in the lining of the anal canal that are often associated with tension and spasms in the internal anal sphincter. This muscle contraction can reduce blood flow to the anus and prevent the fissure from healing. This is the first study to compare topical Diltiazem and Nifedipine in the treatment of chronic anal fissure. 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Vinyl gloves were supplied to improve topical absorption, leaving the thumbs out of the gloves without any cream (control group). All patients underwent a high-frequency color Doppler ultrasound examina-tion before and 1 hour after topical application. The The typical dosing of either 0.2% nitroglycerin ointment or 2% diltiazem cream is twice daily for 6-8 weeks. 4 Topical glyceryl trinitrate is believed to work through its metabolites. It breaks the cycle of spasm by relaxing the internal anal sphincter and reducing resting anal pressure. Buy Nifedipine (Generic Adalat CC, Procardia, Procardia XL) Online | Blink Health nifedipine Nifedipine is used alone or in combination with other drugs to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Many doctors prescribe diltiazem hydrochloride to treat anal fissures. Diltiazem is a calcium channel blocker, which works by dilating blood vessels. 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Nifedipine 0.2% Ointment Diltiazem 2% Ointment Nitroglycerin 0.125% Ointment These ointments are usually applied a few times per day on the affected area and after bowel movements. Lidocaine can be included in nifedipine and diltiazem compounds as an anesthetic for pain relief as well. Nifedipine can be used for conditions other than high blood pressure, including premature labor. If you are prescribed the drug for premature labor it is important to take the medication exactly as instructed by your physician. There is a long list of medications that may interact with nifedipine, including medications for gastrointestinal. Ointment and gel are not commercially available and must be prepared by a licensed compounding facility (Bleday 2019). Intra-anal: 0.2% to 0.3% ointment or gel: Apply on or around fissure(s) 2 to 4 times daily for 4 weeks (Agrawal 2013; Bleday 2019; Ezri 2003).. Immediate release nifedipine should not be used for acute blood pressure reduction. Ezri T, Susmallian S. 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